1. Drug-eluting and bare metal stents

Polymer-free versus durable polymer drug-eluting stents

ISAR-TEST 5: 10 years
Objective
to assess the 10-year clinical outcomes of stenting with polymer-free sirolimus and probucol-eluting stents compared to durable zotarolimus-eluting stents
Study
multicentre randomised 2:1 trial
Population
patients with evidence of ischaemia or ischaemic symptoms excluding left main disease
Endpoints
composite death, target vessel MI, target lesion revascularisation at 10 years
ISAR-TEST 5: 10 years
ISAR-TEST 5: 10 years
Conclusion
there was no difference in the MACE rates at 10-year follow-up between treatment with SES/probucol stent (polymer-free) and ZES stent (durable polymer)
Kufner et al. J Am Coll Cardiol. 2020;76:146-58
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